Prevagen Review: Can Jellyfish Protein Improve Memory? (2024)

Prevagen Review: Can Jellyfish Protein Improve Memory? (1)

Disclaimer: None of the information in this article constitutes medical advice, and is just the opinion of the writer(s). We recommend that patients follow their doctor’s guidance in regard to nootropics.

Prevagen is a popular nootropic supplement, and the brand claims it's the #1 recommended memory supplement by pharmacists. Its active ingredient is a synthetically-derived protein that’s found in jellyfish, called apoaequorin.

But does Prevagen contain ingredients shown in research studies to improve memory? Does it contain any unhealthy additives? Whywas the company warned by the FDA and FTC? And how do real Prevagen users rate and describe the effects of the supplement?

In this article we’ll answer all of these questions and more, as we analyze theingredientsin Prevagen togive our take on whether or not the supplement is likely to be effective, and whether or not it's healthy.

We'll highlight some questionable business practices and legal issues faced by the brand, feature real customer reviews, and discuss the risk of side effects.

IngredientAnalysis

Prevagen Review: Can Jellyfish Protein Improve Memory? (2)

The ingredients in Prevagen Regular Strength are shown above.

Apoaequorin is a protein derived from jellyfish.

A medical review published in The Consultant Pharmacist journal found that this ingredient at the dose in Prevagen Regular Strength improved verbal learning and memory recall measures.

However, it's worth noting that the trial was funded by the manufacturer of Prevagen, which increases the risk of bias.

Vitamin D is the only other active ingredient.

Medical research shows that low levels of vitamin D are associated with accelerated cognitive decline, but we haven't come across any studies proving that vitamin D supplementation in healthy adults without deficiency improves cognition.

Sugaris an inactive ingredient which we consider to be a questionable choice for amemory supplement, given that added sugar intake is positively associated with cognitive impairment,according toa 2016medical review.

Overall, we consider Prevagen Regular Strength to be potentially effective for improving memory, given the effective dose of apoaequorin.

QuestionableBusiness Practices

When the Food and Drug Administration (FDA) inspected Prevagen’s manufacturing facility, they found that the company didn’t have the required quality controls in place to ensure product quality.

An FDA warning letter states that Prevagen’s manufacturing facility “failed to establish release criteria for several manufacturing steps where control is necessary to ensure that specifications for identity, purity, strength and composition are met”.

In layman’s terms this means Prevagen wasn't ensuring that the products they sold contained thestated ingredients at the stated doses.

In 2020, the Federal Trade Commission (FTC) suedPrevagen's manufacturerfor deceptive advertising.

One of the most damningallegations about Prevagen in the above-linked lawsuit is thatthe companymay not have been reporting cases of severecustomerinjury to the FDA, which is a requirement.

Some of their users were alleged to beexperiencing an increase in seizures after takingPrevagen.

The FTClawsuit also alleges that Prevagen's claims of being "clinically shown" to work are false and unsubstantiated.

We consider Prevagen’s claim of “#1 Pharmacist-Recommended Brand” to be questionable, given that Prevagen's manufacturer sponsored an articlein the Pharmacy Timestitled "Pharmacists' Guide toRecommending Prevagen."

In light of all of this information, we recommend avoiding all Prevagen supplements given how the company has historically conducted itself.

Does Prevagen Cause Side Effects?

Prevagen links out to three safety studies on their websiteaboutapoaequorin.

All three are animal studies.

While animal studies are useful for determining toxicity, we would not consider a compound proven to be safebased on animal studies alone.

One of the animal studies cited by Prevagen found no adverse effects when apoaequorin was administered at doses far higher than in Prevagen.

The FDA warning letter referenced in the previous section documented over 1,000 adverse events that were reported while taking Prevagen, including heart arrhythmias, chest pain and vertigo.

We would not necessarilyassumethat these reported side effects were caused by Prevagen, because there will be user complaints for any supplement with millions of users.

Even placebo pills can cause side effects, which is why placebo-controlled studies with human participants are so important. Only side effects experienced above placebo rates are considered to be legitimate.

The human trial on Prevagen reported no serious adverse events, and no higher side effect rate in the trial group than the placebo group, but there were only 218 total participants in the trial.

Overall, wedo not consider Prevagen likely to cause side effects in otherwise healthy individuals based on the available data, but we urge the company to fund more human trials that are placebo-controlled to further prove the safety of their supplement.

YouTuber Tries Prevagen

A YouTube creator named Lori Alcorn shared her experience taking Prevagen:

Is Prevagen Extra StrengthBetter?

Prevagen Review: Can Jellyfish Protein Improve Memory? (3)

Prevagen sells a more potent version of their supplement called Prevagen Extra Strength.

It contains twice the apoaequorin dose (20 mg) as Prevagen Regular Strength.

We would not recommend this supplement and consider its formulation to be inferior to Prevagen Regular Strength, because the dose in Prevagen Regular Strength is the dose that was used in the clinical trial on this ingredient.

While this supplement may be effective for memory enhancement, we cannot recommend it because we can't locate any medical studies proving the safety and efficacy ofapoaequorin at a 20 mg dose.

This supplement also contains added sugar and a relatively high dose of vitamin D, which is a fat-soluble vitamin (meaning it's not as easily excreted in the case of overdose as water-soluble vitamins like B-vitamins).

Prevagen vs. Neuriva

Neuriva is another popular nootropic supplement, so consumers are often curious about which is the better option.

We reviewed Neuriva extensively in a separate Illuminate Health review, and we would recommend it over Prevagen (though we don't currently recommend either supplement).

Neuriva Original and Neuriva Plus both contain two effective nootropic ingredients that are clinically proven to work, and both of which have more research backing than we could findon the active ingredient in Prevagen.

And while Neuriva has also faced a lawsuit over health claims made on their website, we consider Prevagen's business practices to be more questionable overall in light of both FDA and FTC actions.

OurClean Nootropic Picks

Prevagen Review: Can Jellyfish Protein Improve Memory? (4)

Mind Lab Proby Performance Lab is our top premium nootropic pick.

This is the first Illuminate Labs Certified supplement, andhas been shown to be effective for short-term cognitive improvements intwoclinicaltrialspublished in peer-reviewed journals.

Performance Lab MCT Oilis our topfood-based nootropic pick.

MCT oilis derived from coconut oil, andimproved memory recall by 20% in adultsin a 2022meta-study.

Illuminate Labs Ginkgo Biloba Extractis our top herbal nootropic pick.

Amedical reviewpublished in thePsychopharmacologyjournalfound that ginkgo biloba supplementation improved attention and cognitive performance in healthy, young adults.

Customers Rate Prevagen

Prevagen Regular Strength has been reviewed over 5,000 times on Amazon, and has an average review rating of 4.3 out of 5 stars at the time of updating this article.

Atop positive review from a verified purchaser comes from a user named "Rosemary S." who gave the supplement a 5/5 rating:

"I am starting to have memory issues and I believe prevargen is helpful. I don't use it all the time but if I want to feel more secure with my memory for a certain occasion I rely on Prevagen."

Atop negative review from a verified purchaser is written by a user named "Victor from Tx" who gave the supplement a 1/5 rating:

"On receipt, I noticed that the bulk of the supplement is vitamin D which can be procured at a much lower price. The so called active ingredient is apoaequorin for which the consensus in the articles I read, is that it is digested in the stomach and does not reach the brain. Given that very little, if any, makes it to the brain, I thought that the potential side effects relative to the benefits (near zero) makes this supplement one that I should be avoiding."

Prevagen Regular Strength currently has an average review rating of 4.3 out of 5 stars on Google.

Prevagen Pros and Cons

Here are the pros and cons of Prevagen in our opinion:

Pros:

  • Potentially effective
  • Legitimate clinical trial with favorable results
  • Side effectsseem unlikely based on formulation
  • Relatively positive online customer reviews

Cons:

  • Contains added sugar
  • Received FDA warning letter
  • Sued by FTC for misleading claims
  • Worse formulation than Neuriva
  • Extra Strength contains unproven apoaequorin dose

Conclusion

We do not currently recommend any Prevagen supplements, and we recommend avoiding this brand entirely in light of the FDA warning letter and FTC lawsuit.

While Prevagen may be effective for enhancing memory, we are only able to identify one clinical trial proving so, and that clinical trial was funded by the supplement's manufacturer.

Prevagen contains added sugar,which is an ingredient we recommend avoiding unless otherwiserecommended by a doctor.

For consumers set on purchasing Prevagen, we would recommend Prevagen Regular StrengthoverPrevagen Extra Strength, because the former is cheaper andcontains the formulation used in the human trial.

We consider Neuriva (another popular nootropic supplement) to be better-formulated than Prevagen.

Prevagen Review: Can Jellyfish Protein Improve Memory? (2024)
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